Biochemistry WGU

Oxygenated vs de group Oated states of blood One hemoglobin can lead 4 oxygen Deoxygenated hemoglobin is not bound to oxygen If a person has unhopeful oxygen level, a bluish hue go away go out and a low pulse oxygenation forget register as a measurement of the difference between oxygenated and deoxygenated hemoglobin. *Hemoglobin transports oxygen to cells and C02 to lungs to be exhaled. **Deoxygenated hemoglobin is concave shape oxygenated is planar shape and red in arteries Hemoglobin (2013) Bohr Effect Lower blood pH or high blood C02 = hemoglobin proteins oxygenLower C02 or higher pH = hemoglobin + oxygen Myoglobin has no allostery, does not display Bohr effect High C02, high H+, low partial = oxygen from hemoglobin High C02 or low pH = increase of oxygen in tissues Bohr Effect (2013) Oxygen proportion and pH Bohr Shift Carbonic window pane = lower blood pH Lower blood pH = Bohr Shift (oxygen from hemoglobin) wolfe (2000) Hemoglobin and Myoglobin Myoglobin Binds iron, st ores oxygen OF2 ADnormal, result 0T an Injury to muscle Myoglobin = heme + iron + 8 amino acid chains in alpha helix HemoglobinTransports oxygen from lungs to tissues Contains iron (Hemoglobin 2013) Sickcle mobile phone Abnormal, sickle cell shaped RBCs Sickle cells stop blood flow, genuinely painful riddle valine in place of glutamic amino acid do cells to stick together Problem cells are rigid and inflexible Problem normal RBCs live 90-120, sickle cells live 10-20 days, shorter lifespan results in anaemia Inheritance Autosomal recessive disease inherited from parents Carrier parents will produce offspring with a 14 chance of acquire sickle cell disease .